A High-risk Haplotype for Premature Menopause in Childhood Cancer Survivors Exposed to Gonadotoxic Therapy
نویسندگان
چکیده
منابع مشابه
Occult cardiotoxicity in childhood cancer survivors exposed to anthracycline therapy.
BACKGROUND More than 50% of >270 000 childhood cancer survivors in the United States have been treated with anthracyclines and are therefore at risk of developing cardiotoxicity. Cardiac magnetic resonance (CMR) has demonstrated utility to detect diffuse interstitial fibrosis and changes in regional myocardial function. We hypothesized that CMR would identify occult cardiotoxicity characterized...
متن کاملScreening for cardiac dysfunction in anthracycline-exposed childhood cancer survivors.
PURPOSE To examine the utility and reliability of obtaining early echocardiographic measurements of left ventricular (LV) remodeling as well as blood biomarkers of cardiac injury in asymptomatic childhood cancer survivors at risk for LV dysfunction and congestive heart failure due to past exposure to anthracycline chemotherapy. EXPERIMENTAL DESIGN Using a cross-sectional design, anthracycline...
متن کاملAge at menopause and its influencing factors in a cohort of survivors of childhood cancer: earlier but rarely premature.
STUDY QUESTION Is the age at menopause in a cohort of childhood cancer survivors earlier and what are the risk factors associated with earlier age at menopause? SUMMARY ANSWER Menopause occurred at a median age of 44 years in this cohort which is earlier than in the general population, but premature menopause was uncommon. Main risk factors for non-surgical menopause were exposure to and dose...
متن کاملEvaluating Sleep Habits and Related Factors in Childhood Cancer Survivors: A Cross‐Sectional Study
Background: Sleep habits may play a role in the onset of sleep disorders. Several factors affect sleep habits. This study aimed to investigate sleep habits and related factors in childhood cancer survivors (CCS). Materials and Methods: This cross-sectional study was performed on 400 children (age range: 5-15 years) who recovered from cancer in Tehran, Iran, in 2020. A 35-item Children's Sleep ...
متن کاملDefining late onset occult asymptomatic cardiotoxicity in childhood cancer survivors exposed to anthracycline therapy: a cardiac magnetic resonance imaging study
Background There are over 270,000 childhood cancer survivors in the US. Of these survivors, more than 50% have been treated with anthracyclines and are at risk of developing progressive cardiotoxicity. Novel cardiac magnetic resonance imaging (CMRI) techniques are now able to reliably detect diffuse myocardial fibrosis and changes in regional myocardial function. We hypothesized that these nove...
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ژورنال
عنوان ژورنال: JNCI: Journal of the National Cancer Institute
سال: 2018
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/djx281